Integrative analysis of the association between circadian rhythm and lupus nephritis.

ABSTRACT:

Background

Lupus nephritis (LN) is an autoimmune nephropathy associated with systemic lupus erythematosus. Circadian rhythms are involved in the development of several diseases, especially inflammation-related diseases, but their relationship with LN is unclear.

Methods

This was an integrative bioinformatics study. The expression profile from glomeruli, tubular interstitium and renal whole tissue samples was used to assess the expression levels and relevance of circadian rhythm-related genes. To screen for circadian rhythm-related signatures, we employed the LASSO and SVM-RFE algorithms. A consensus clustering algorithm was used to classify LN patients into two circadian rhythm patterns (cluster A and cluster B). We made immune cell infiltration analysis. We used the weighte

SUBMITTER: Jin M 

PROVIDER: S-EPMC10469101 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature