Women's representation in clinical trials of patients with chronic kidney disease.

ABSTRACT:

Background

Sex and gender differences in chronic kidney disease (CKD), including epidemiology and response to treatment, remain poorly understood. This study aimed to investigate how women are represented in CKD clinical trials and whether sex- and gender-disaggregated outcomes were reported.

Methods

Clinical trials on CKD were identified from ClinicalTrials.gov. Randomised, phase 3/4 trials with ≥100 participants were selected to quantify women's representation among participants by computing the participation:prevalence ratio (PPR) and investigating whether sex-disaggregated analyses had been performed.

Results

In total, 192 CKD trials registered on ClinicalTrials.gov and published between 1995 and 2022 were included. Overall, women accounted for 66 875 (45%) of the

SUBMITTER: Pinho-Gomes AC 

PROVIDER: S-EPMC10469102 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature