Integrated multi-omics analysis reveals the molecular interplay between circadian clocks and cancer pathogenesis.

ABSTRACT: Circadian rhythms (CRs) are fundamental biological processes that significantly impact human well-being. Disruption of these rhythms can trigger insufficient neurocognitive development, insomnia, mental disorders, cardiovascular diseases, metabolic dysfunctions, and cancer. The field of chronobiology has increased our understanding of how rhythm disturbances contribute to cancer pathogenesis, and how circadian timing influences the efficacy of cancer treatments. As the circadian clock steadily gains recognition as an emerging factor in tumorigenesis, a thorough and comprehensive multi-omics analysis of CR genes/proteins has never been performed. To shed light on this, we performed, for the first time, an integrated data analysis encompassing genomic/transcriptomic alterations across 32 can

SUBMITTER: Perez-Villa A 

PROVIDER: S-EPMC10469199 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature