Prenatal Antidepressant Exposure and Offspring Brain Morphologic Trajectory.

ABSTRACT:

Importance

Clinical decision-making on antidepressant treatment during pregnancy, particularly selective serotonin reuptake inhibitors (SSRIs), is challenging, as both prenatal SSRI exposure and maternal depressive symptoms may be associated with negative outcomes in offspring.

Objective

To investigate the association between intrauterine SSRI exposure and maternal depressive symptoms and structural brain development in offspring from mid-childhood to early puberty.

Design, setting, and participants

This prospective, population-based cohort study was embedded in the Generation R Study in Rotterdam, the Netherlands. All pregnant individuals with an expected delivery date between April 1, 2002, and January 31, 2006, were invited to participate. Data were analyzed from F

SUBMITTER: Koc D 

PROVIDER: S-EPMC10469300 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature