The causal effect of serum micronutrients on malignant kidney neoplasm in European descent.

ABSTRACT:

Purpose

Observational studies have revealed that serum minerals and vitamins are associated with cancer. However, the causal relationships between serum minerals and vitamins and renal malignancies remain unclear.

Methods

Mendelian randomization (MR) was used for causal estimation. Single nucleotide polymorphisms (SNPs) for serum minerals and vitamins were obtained from published genome-wide association studies (GWAS). GWAS for malignant kidney neoplasm was obtained from the FinnGen consortium. Methods of inverse variance weighted (IVW), MR-Egger, and weighted median were carried out for causal inference. F-statistic was calculated to ensure a robust instrumental variable. Cochran's Q statistics was applied to calculate heterogeneity. MR-Egger regression, MR-pleiotropy resid

SUBMITTER: Qiao P 

PROVIDER: S-EPMC10469310 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature