Ki-67, 21-Gene Recurrence Score, Endocrine Resistance, and Survival in Patients With Breast Cancer.

ABSTRACT:

Importance

Both high 21-gene recurrence score (RS) and high Ki-67 level are poor prognostic factors in patients with estrogen receptor (ER)-positive ERBB2-negative (ER+/ERBB-) breast cancer; however, a discrepancy between the 2 has been noted. Survival differences according to these 2 biomarkers are not well known.

Objective

To assess the associations between RS and Ki-67 expression and between Ki-67 expression and recurrence-free survival in patients with ER+/ERBB- breast cancer with low RS.

Design, setting, and participants

This cohort study included women treated for ER+/ERBB2- breast cancer who underwent the 21-gene RS test from March 2010 to December 2020 in 2 hospitals in Korea.

Exposures

Recurrence score and Ki-67 level.

Main outcomes and measures

SUBMITTER: Lee J 

PROVIDER: S-EPMC10469325 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature