Bcl6, Irf2, and Notch2 promote nonclassical monocyte development.

ABSTRACT: Ly6C^lo monocytes are a myeloid subset that specializes in the surveillance of vascular endothelium. Ly6C^lo monocytes have been shown to derive from Ly6C^hi monocytes. NOTCH2 signaling has been implicated as a trigger for Ly6C^lo monocyte development, but the basis for this effect is unclear. Here, we examined the impact of NOTCH2 signaling of myeloid progenitors on the development of Ly6C^lo monocytes in vitro. NOTCH2 signaling induced by delta-like ligand 1 (DLL1) efficiently induced the transition of Ly6C^hi TREML4^- monocytes into Ly6C^lo TREML4⁺ monocytes. We further identified two additional transcriptional requirements for development of Ly6C^lo monocytes. Deletion of BCL6 from myel

SUBMITTER: O'Connor KW 

PROVIDER: S-EPMC10469339 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature