Impact of national recommendations for routine pertussis vaccination during pregnancy on infant pertussis in Ontario, Canada: a population-based time-series study.

ABSTRACT:

Background

In February 2018, Canada's National Advisory Committee on Immunization (NACI) recommended antenatal tetanus-diphtheria-acellular pertussis (Tdap) immunization in every pregnancy regardless of previous Tdap immunization history. We examined the impact of the NACI recommendation on rates of infant pertussis in Ontario, Canada.

Methods

We conducted a population-based time-series study of all live births in Ontario between August 1, 2011 and February 28, 2020. We used interventional autoregressive integrated moving average models to examine the impact of the NACI recommendation on monthly rates of pertussis among infants ≤ 3 months of age.

Results

We observed 675 incident cases of pertussis among 1,368,024 infants 3 months of age or less between August 2011 and

SUBMITTER: Antoniou T 

PROVIDER: S-EPMC10469528 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature