Regulation of the stem‑like properties of estrogen receptor‑positive breast cancer cells through NR2E3/NR2C2 signaling.

ABSTRACT: Cancer stem cells (CSCs) are major drivers of metastasis, drug resistance and recurrence in numerous cancers. However, critical factors that can modulate CSC stemness have not been clearly identified. Nuclear receptor subfamily 2 group E member 3 (nr2e3) expression has been previously reported to be positively associated with drug sensitivity and favorable clinical outcomes in patients with estrogen receptor (ER)⁺ breast cancer. This suggests that nr2e3 expression may be inversely associated with CSC stemness in this type of tumor cells. The present study aimed to investigate the regulatory roles of NR2E3 in the stem-like properties of ER⁺ breast cancer cells and to identify the underlying mechanisms. Bioinformatics analysis was performed using the data

SUBMITTER: Xie S 

PROVIDER: S-EPMC10469576 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature