Neuroprotective effect of dexmedetomidine on autophagy in mice administered intracerebroventricular injections of Aβ_25-35.

ABSTRACT: Alzheimer's disease (AD), one of the most prevalent neurodegenerative diseases is associated with pathological autophagy-lysosomal pathway dysfunction. Dexmedetomidine (Dex) has been suggested as an adjuvant to general anesthesia with advantages in reducing the incidence of postoperative cognitive dysfunction in Dex-treated patients with AD and older individuals. Several studies reported that Dex improved memory; however, evidence on the effects of Dex on neuronal autophagy dysfunction in the AD model is lacking. We hypothesized that Dex administration would have neuroprotective effects by improving pathological autophagy dysfunction in mice that received an intracerebroventricular (i.c.v.) injection of amyloid β-protein fragment 25-35 (Aβ_25-35) and in an autophagy-deficient cel

SUBMITTER: Lee YY 

PROVIDER: S-EPMC10469611 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature