T-cells infiltration mediates the association between neutrophil/lymphocyte ratio and survival in gastric cancer.

ABSTRACT:

Background

Neutrophil/lymphocyte ratio (NLR) is a vital index for systemic inflammation and a prognostic indicator for gastric cancer (GC). Despite the abundant literature on NLR's prognostic value for GC, the underlying factors mediating its impact on survival remain unclear. The objective of this study was to analyze the role of NLR in different prognostic models and subgroups, and investigate the mediating effects of immune infiltrates between NLR and survival.

Methods

A total of 924 patients who underwent D2 lymph node resection were enrolled in this study. According to the level of NLR, patients were divided into two groups, the high and low NLR groups. Clinical parameters, indexes related to immune infiltrates, and survival were compared between the two groups. Prognos

SUBMITTER: He Q 

PROVIDER: S-EPMC10469634 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature