Dataset Information

Clinical features and prognosis of patients with metastatic ocular and orbital melanoma: A bi-institutional study.

ABSTRACT:

Purpose

Metastatic ocular and orbital melanomas are extremely rare. The clinical characteristics and standard treatments for these patients are not fully established.

Materials and methods

We retrospectively analyzed patients with metastatic ocular and orbital melanoma from Fudan University Shanghai Cancer Center and Eye & ENT Hospital of Fudan University between January 2012 and May 2022.

Results

Overall, 51 patients with metastatic ocular and orbital melanoma were included. The most common primary sites were uvea (73%), followed by conjunctiva (22%), lacrimal sac (4%), and orbit (2%). Patients with uveal melanoma (UM) had a significantly younger age (48 vs. 68 years, p < 0.001), higher incidence of liver metastases (89% vs. 9%, p<0.001), a lower incidence of lymph nodes metastases (16% vs. 46%, p = 0.043) and a lower incidence of BRAF mutation (0% vs. 55%, p<0.001) compared with patients with conjunctival melanoma (CM). The overall response rate of the first-line treatment was 18%. Three of the four patients with BRAF-mutated CM responded to dabrafenib and trametinib treatment. The median progression-free survival (PFS) and overall survival (OS) of first-line treatment were 5.1 and 11.9 months, respectively. Among patients with liver metastases, liver-directed treatment was correlated with better patient PFS (p < 0.001) and OS (p < 0.001) after adjusting for number of metastatic sites and primary sites.

Conclusion

CM and UM have different characteristics. Patient with CM had a high incidence of BRAF mutation, and the treatment of BRAF and MEK inhibitors conferred clinical benefit. Liver directed therapies had a potential benefit in disease control in patients with liver metastases.

SUBMITTER: Liu X

PROVIDER: S-EPMC10469730 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature

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Publications

Clinical features and prognosis of patients with metastatic ocular and orbital melanoma: A bi-institutional study.

Liu Xin X Yue Han H Jiang Shiyu S Kong Lin L Xu Yu Y Chen Yong Y Wang Chunmeng C Wang Yan Y Zhu Xiaoli X Kong Yunyi Y Zhang Xiaowei X Qian Jiang J Luo Zhiguo Z

Cancer medicine 20230706 15

<h4>Purpose</h4>Metastatic ocular and orbital melanomas are extremely rare. The clinical characteristics and standard treatments for these patients are not fully established.<h4>Materials and methods</h4>We retrospectively analyzed patients with metastatic ocular and orbital melanoma from Fudan University Shanghai Cancer Center and Eye & ENT Hospital of Fudan University between January 2012 and May 2022.<h4>Results</h4>Overall, 51 patients with metastatic ocular and orbital melanoma were include ...[more]

PMID: 37409486

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Dataset Information

Clinical features and prognosis of patients with metastatic ocular and orbital melanoma: A bi-institutional study.

Purpose

Materials and methods

Results

Conclusion

Publications

Clinical features and prognosis of patients with metastatic ocular and orbital melanoma: A bi-institutional study.

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