Clinical features and prognosis of patients with metastatic ocular and orbital melanoma: A bi-institutional study.

ABSTRACT:

Purpose

Metastatic ocular and orbital melanomas are extremely rare. The clinical characteristics and standard treatments for these patients are not fully established.

Materials and methods

We retrospectively analyzed patients with metastatic ocular and orbital melanoma from Fudan University Shanghai Cancer Center and Eye & ENT Hospital of Fudan University between January 2012 and May 2022.

Results

Overall, 51 patients with metastatic ocular and orbital melanoma were included. The most common primary sites were uvea (73%), followed by conjunctiva (22%), lacrimal sac (4%), and orbit (2%). Patients with uveal melanoma (UM) had a significantly younger age (48 vs. 68 years, p < 0.001), higher incidence of liver metastases (89% vs. 9%, p<0.001), a lower incidence of lymph n

SUBMITTER: Liu X 

PROVIDER: S-EPMC10469730 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature