Agonism of 4-1BB for immune therapy: a perspective on possibilities and complications.

ABSTRACT: Costimulatory receptors on immune cells represent attractive targets for immunotherapy given that these molecules can increase the frequency of individual protective immune cell populations and their longevity, as well as enhance various effector functions. 4-1BB, a member of the TNF receptor superfamily, also known as CD137 and TNFRSF9, is one such molecule that is inducible on several cell types, including T cells and NK cells. Preclinical studies in animal models have validated the notion that stimulating 4-1BB with agonist reagents or its natural ligand could be useful to augment conventional T cell and NK cell immunity to protect against tumor growth and against viral infection. Additionally, stimulating 4-1BB can enhance regulatory T cell function and might be useful in the right con

SUBMITTER: Salek-Ardakani S 

PROVIDER: S-EPMC10469789 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature