Identification of immune-related biomarkers co-occurring in acute ischemic stroke and acute myocardial infarction.

ABSTRACT:

Background

Acute ischemic stroke (AIS) and acute myocardial infarction (AMI) share several features on multiple levels. These two events may occur in conjunction or in rapid succession, and the occurrence of one event may increase the risk of the other. Owing to their similar pathophysiologies, we aimed to identify immune-related biomarkers common to AIS and AMI as potential therapeutic targets.

Methods

We identified differentially expressed genes (DEGs) between the AIS and control groups, as well as AMI and control groups using microarray data (GSE16561 and GSE123342). A weighted gene co-expression network analysis (WGCNA) approach was used to identify hub genes associated with AIS and/or AMI progression. The intersection of the four gene sets identified key genes, which we

SUBMITTER: Wang S 

PROVIDER: S-EPMC10469875 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature