Metabolomics analysis of visceral leishmaniasis based on urine of golden hamsters.

ABSTRACT:

Background

Leishmaniasis is one of the most neglected tropical diseases and is spread mainly in impoverished regions of the world. Although many studies have focused on the host's response to Leishmania invasion, relatively less is known about the complex processes at the metabolic level, especially the metabolic alterations in the infected hosts.

Methods

In this study, we conducted metabolomics analysis on the urine of golden hamsters in the presence or absence of visceral leishmaniasis (VL) using the ultra-performance liquid chromatography (UPLC) system tandem high-resolution mass spectrometer (HRMS). The metabolic characteristics of urine samples, along with the histopathological change and the parasite burden of liver and spleen tissues, were detected at 4 and 12 weeks p

SUBMITTER: Yuan D 

PROVIDER: S-EPMC10469881 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature