Delineating intra-tumoral heterogeneity and tumor evolution in breast cancer using precision-based approaches.

ABSTRACT: The burden of breast cancer continues to increase worldwide as it remains the most diagnosed tumor in females and the second leading cause of cancer-related deaths. Breast cancer is a heterogeneous disease characterized by different subtypes which are driven by aberrations in key genes such as BRCA1 and BRCA2, and hormone receptors. However, even within each subtype, heterogeneity that is driven by underlying evolutionary mechanisms is suggested to underlie poor response to therapy, variance in disease progression, recurrence, and relapse. Intratumoral heterogeneity highlights that the evolvability of tumor cells depends on interactions with cells of the tumor microenvironment. The complexity of the tumor microenvironment is being unraveled by recent advances in screening tec

SUBMITTER: Xulu KR 

PROVIDER: S-EPMC10469897 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature