Integrated multi-omic analyses provide insight into colon adenoma susceptibility modulation by the gut microbiota.

ABSTRACT: Colon cancer onset is strongly associated with the differences in microbial taxa in the gastrointestinal tract. Although recent studies highlight the role of individual taxa, the effect of a complex gut microbiome (GM) on the metabolome and host transcriptome is still unknown. We used a multi-omics approach to determine how differences in the GM affect the susceptibility to adenoma development in a rat model of human colon cancer. Ultra-high performance liquid chromatography mass spectrometry of feces collected prior to observable disease onset identified putative metabolite profiles that likely predict future disease severity. Transcriptome analyses performed after disease onset from normal colonic epithelium and tumor tissues show a correlation between GM and host gene expression. Integr

SUBMITTER: Busi SB 

PROVIDER: S-EPMC10469915 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature