An anoikis-related gene signature for prediction of the prognosis in prostate cancer.

ABSTRACT:

Purpose

This study presents a novel approach to predict postoperative biochemical recurrence (BCR) in prostate cancer (PCa) patients which involves constructing a signature based on anoikis-related genes (ARGs).

Methods

In this study, we utilised data from TCGA-PARD and GEO databases to identify specific ARGs in prostate cancer. We established a signature of these ARGs using Cox regression analysis and evaluated their clinical predictive efficacy and immune-related status through various methods such as Kaplan-Meier survival analysis, subject work characteristics analysis, and CIBERSORT method. Our findings suggest that these ARGs may have potential as biomarkers for prostate cancer prognosis and treatment. To investigate the biological pathways of genes associated with anoi

SUBMITTER: Zhao X 

PROVIDER: S-EPMC10469923 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature