A novel cuproptosis pattern and tumor immune microenvironment characterization in urothelial carcinoma of the bladder.

ABSTRACT:

Background

Urothelial carcinoma of the bladder (UCB) is the most prevalent malignant tumor of the urinary system worldwide, which has a significant recurrence rate despite multiple treatment options available. As a unique and novel copper-dependent programmed cell death mechanism, the comprehensive impact of cuproptosis on the tumor immune microenvironment, clinicopathological characteristics and the prognosis of patients remains largely unclear.

Methods

A total of 568 UCB samples were thoroughly examined for cuproptosis patterns using data downloaded from TCGA and GEO, based on 10 cuproptosis-related genes reported previously. Then, the univariate COX regression analysis was performed on the genes that differed across the various patterns. To measure individual cuproptosis

SUBMITTER: Feng H 

PROVIDER: S-EPMC10469981 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature