The combined signatures of telomere and immune cell landscape provide a prognostic and therapeutic biomarker in glioma.

ABSTRACT:

Background

Gliomas, the most prevalent primary malignant tumors of the central nervous system in adults, exhibit slow growth in lower-grade gliomas (LGG). However, the majority of LGG cases progress to high-grade gliomas, posing challenges for prognostication. The tumor microenvironment (TME), characterized by telomere-related genes and immune cell infiltration, strongly influences glioma growth and therapeutic response. Therefore, our objective was to develop a Telomere-TME (TM-TME) classifier that integrates telomere-related genes and immune cell landscape to assess prognosis and therapeutic response in glioma.

Methods

This study encompassed LGG patients from the TCGA and CCGA databases. TM score and TME score were derived from the expression signatures of telomere-related

SUBMITTER: Han X 

PROVIDER: S-EPMC10470026 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature