Identification of distinct impacts of CovS inactivation on the transcriptome of acapsular group A streptococci.

ABSTRACT: Group A streptococcal (GAS) strains causing severe, invasive infections often have mutations in the control of virulence two-component regulatory system (CovRS) which represses capsule production, and high-level capsule production is considered critical to the GAS hypervirulent phenotype. Additionally, based on studies in emm1 GAS, hyperencapsulation is thought to limit transmission of CovRS-mutated strains by reducing GAS adherence to mucosal surfaces. It has recently been identified that about 30% of invasive GAS strains lacks capsule, but there are limited data regarding the impact of CovS inactivation in such acapsular strains. Using publicly available complete genomes (n = 2,455) of invasive GAS strains, we identified similar rates of CovRS inactivation and limited evide

SUBMITTER: DebRoy S 

PROVIDER: S-EPMC10470059 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature