Human T cells loaded with superparamagnetic iron oxide nanoparticles retain antigen-specific TCR functionality.

ABSTRACT:

Background

Immunotherapy of cancer is an emerging field with the potential to improve long-term survival. Thus far, adoptive transfer of tumor-specific T cells represents an effective treatment option for tumors of the hematological system such as lymphoma, leukemia or myeloma. However, in solid tumors, treatment efficacy is low owing to the immunosuppressive microenvironment, on-target/off-tumor toxicity, limited extravasation out of the blood vessel, or ineffective trafficking of T cells into the tumor region. Superparamagnetic iron oxide nanoparticles (SPIONs) can make cells magnetically controllable for the site-specific enrichment.

Methods

In this study, we investigated the influence of SPION-loading on primary human T cells for the magnetically targeted adoptive T cell

SUBMITTER: Pfister F 

PROVIDER: S-EPMC10470061 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature