Elucidating the roles of the mammary and gut microbiomes in breast cancer development.

ABSTRACT: The mammary microbiome is a newly characterized bacterial niche that might offer biological insight into the development of breast cancer. Together with in-depth analysis of the gut microbiome in breast cancer, current evidence using next-generation sequencing and metabolic profiling suggests compositional and functional shifts in microbial consortia are associated with breast cancer. In this review, we discuss the fundamental studies that have progressed this important area of research, focusing on the roles of both the mammary tissue microbiome and the gut microbiome. From the literature, we identified the following major conclusions, (I) There are unique breast and gut microbial signatures (both compositional and functional) that are associated with breast cancer, (II) breast and gut mi

SUBMITTER: Hoskinson C 

PROVIDER: S-EPMC10470065 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature