Developing and validating a nomogram for cognitive impairment in the older people based on the NHANES.

ABSTRACT:

Objective

To use the United States National Health and Nutrition Examination Study (NHANES) to develop and validate a risk-prediction nomogram for cognitive impairment in people aged over 60 years.

Methods

A total of 2,802 participants (aged ≥ 60 years) from NHANES were analyzed. The least absolute shrinkage and selection operator (LASSO) regression model and multivariable logistic regression analysis were used for variable selection and model development. ROC-AUC, calibration curve, and decision curve analysis (DCA) were used to evaluate the nomogram's performance.

Results

The nomogram included five predictors, namely sex, moderate activity, taste problem, age, and education. It demonstrated satisfying discrimination with a AUC of 0.744 (95% confidence interval, 0.69

SUBMITTER: Ma X 

PROVIDER: S-EPMC10470068 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature