Helicobacter pylori infection altered gastric microbiota in patients with chronic gastritis.

ABSTRACT:

Objective

The present study aims to investigate the effect of Helicobacter pylori (Hp) infection on gastric mucosal microbiota in patients with chronic gastritis.

Methods

Here recruited a population of 193 patients with both chronic gastritis and positive rapid urease, including 124 patients with chronic atrophic gastritis (CAG) and 69 patients with chronic non-atrophic gastritis (nCAG). Immunoblotting was used to detect four serum Hp antibodies (UreA, UreB, VacA and CagA) to determine the types of virulent Hp-I and avirulent Hp-II infections. Gastric microbiota was profiled by 16S rRNA gene V3-V4 region, and R software was used to present the relationship between the microbial characteristics and the type of Hp infection.

Results

In the stomach of patients wit

SUBMITTER: Hua Z 

PROVIDER: S-EPMC10470091 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature