Transcriptome-guided metabolic network analysis reveals rearrangements of carbon flux distribution in <i>Neisseria gonorrhoeae</i> during neutrophil co-culture.

ABSTRACT: The ability of bacterial pathogens to metabolically adapt to the environmental conditions of their hosts is critical to both colonization and invasive disease. Infection with Neisseria gonorrhoeae (the gonococcus, Gc) is characterized by the influx of neutrophils [polymorphonuclear leukocytes (PMNs)], which fail to clear the bacteria and make antimicrobial products that can exacerbate tissue damage. The inability of the human host to clear Gc infection is particularly concerning in light of the emergence of strains that are resistant to all clinically recommended antibiotics. Bacterial metabolism represents a promising target for the development of new therapeutics against Gc. Here, we generated a curated genome-scale metabolic network reconstruction (GENRE) of Gc strain FA1090. Thi

SUBMITTER: Potter AD 

PROVIDER: S-EPMC10470122 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature