α-Blocker Use in Hemodialysis: The Japan Dialysis Outcomes and Practice Patterns Study.

ABSTRACT:

Rationale & objective

Despite α-blockers' use for hypertension as add-on therapy in patients treated with hemodialysis, scant information is available on their association, particularly with safety, in these patients.

Study design

Prospective cohort study.

Setting & participants

patients treated with hemodialysis and receiving antihypertensive agents in the Japan Dialysis Outcomes and Practice Patterns Study, phases 4-6, were analyzed.

Exposure

Primary exposure was the prescription of α-blocking antihypertensive agents at baseline.

Outcomes

Incident fractures, falls, and all-cause mortality.

Analytical approach

Multivariable Cox and modified Poisson regression analysis.

Results

Of 5,149 patients treated with hemodialysis (mean age, 65 years

SUBMITTER: Iseri K 

PROVIDER: S-EPMC10470217 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature