Sex disparities in non-small cell lung cancer: mechanistic insights from a cRaf transgenic disease model

ABSTRACT: Summary

Background

Women are at greater risk of developing non-small cell lung cancer (NSCLC), yet the underlying causes remain unclear.

Methods

We performed whole genome scans in lung tumours of cRaf transgenic mice and identified miRNA, transcription factor and hormone receptor dependent gene regulations. We confirmed hormone receptors by immunohistochemistry and constructed regulatory gene networks by considering experimentally validated miRNA-gene and transcription factor-miRNA/gene targets. Bioinformatics, genomic foot-printing and gene enrichment analysis established sex-specific circuits of lung tumour growth. Translational research involved a large cohort of NSCLC patients. We evaluated commonalities in sex-specific NSCLC gene regulations between mice and humans a

SUBMITTER:  

PROVIDER: S-EPMC10470261 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature