Genetically predicted waist-to-hip circumference ratio and coronary artery disease: A sex-specific Mendelian randomization study.

ABSTRACT: Coronary artery disease (CAD) affects millions of individuals worldwide and results in a substantial burden to healthcare systems. Although it is established that CAD affects females differently than males, differences between the sexes are not routinely accounted for. Body mass index is a known risk factor for CAD. However, more accurate metrics of body fat, including waist-to-hip circumference ratio (WHR), could be more meaningful clinically. WHR exhibits sex differences due to sex hormones, differing effects at genetic risk loci, and other factors. It is unclear if WHR is a causal factor for CAD in one or both sexes, but this information will be crucial for improving heart health. Causal inference, however, can be challenging. Large-scale cohorts with genetic data allow for Mendelian ra

SUBMITTER: Ye Q 

PROVIDER: S-EPMC10470280 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature