Metformin and Aspirin: Anticancer effects on A549 and PC3 cancer cells and the mechanisms of action.

ABSTRACT: Metformin exerts its anticancer effect through two mechanisms, directly affecting the tumor and indirectly reducing systemic insulin levels. The anticancer effects of aspirin occur by inhibiting Cyclooxygenase (COX)-2. COX-2 is absent in many cell types under normal conditions and increases under pathological conditions such as cancer. This study aims to investigate the effect of metformin and aspirin and their combination of them on A549 and PC3 cell lines. Metformin and aspirin were investigated separately and in combination on two cancer cell lines, A549 and PC3. The examined groups include the negative control of untreated cells and the positive control of cisplatin and drugs at concentrations of 15, 10, and 20 μg/ mL to investigate the mechanism of oxidative stress factors (reactive o

SUBMITTER: Motafeghi F 

PROVIDER: S-EPMC10470367 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature