Hematopoietic stem and progenitor cells confer cross-protective trained immunity in mouse models.

ABSTRACT: Recent studies suggest that infection reprograms hematopoietic stem and progenitor cells (HSPCs) to enhance innate immune responses upon secondary infectious challenge, a process called "trained immunity." However, the specificity and cell types responsible for this response remain poorly defined. We established a model of trained immunity in mice in response to Mycobacterium avium infection. scRNA-seq analysis revealed that HSPCs activate interferon gamma-response genes heterogeneously upon primary challenge, while rare cell populations expand. Macrophages derived from trained HSPCs demonstrated enhanced bacterial killing and metabolism, and a single dose of recombinant interferon gamma exposure was sufficient to induce similar training. Mice transplanted with influenza-trai

SUBMITTER: Kain BN 

PROVIDER: S-EPMC10470378 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature