Ontology highlight
ABSTRACT:
SUBMITTER: Wu J
PROVIDER: S-EPMC10470393 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Wu Jinyan J Huang Yaxian Y Zhan Chi C Chen Lingling L Lin Zhengmei Z Song Zhi Z
iScience 20230811 9
Treatment of periodontitis in people with diabetes remains challenging. The present study aimed to investigate the therapeutic potential of thioredoxin-1 (TRX1) in periodontitis with diabetes, as well as its role in modulating osteogenic differentiation. Our findings indicated that the production of reactive oxygen species (ROS) was elevated, while the expression of TRX1 was significantly reduced in the periodontal tissues of periodontitis mice with diabetes. Furthermore, knockdown of TRX1 in pe ...[more]