Cryptosporidium parvum-induced neutrophil extracellular traps in neonatal calves is a stage-independent process

ABSTRACT:

Introduction

Infections with the apicomplexan obligate intracellular parasite Cryptosporidium parvum lead to cryptosporidiosis—a worldwide zoonotic infection. C. parvum is one of the most common diarrheal pathogens in young calves, which are the main reservoir of the pathogen. Cryptosporidiosis leads to severe economic losses in the calf industry and being a major contributor to diarrhea morbidity and mortality in children. Polymorphonuclear neutrophils (PMN) are part of the innate immune system. Their effector mechanisms directed against invasive parasites include phagocytosis, production of antimicrobial molecules as well as the formation of so-called neutrophil extracellular traps (NETs). Like other leukocytes of the innate immune system, PMN are thus able to release chromatin

SUBMITTER: Grabbe M 

PROVIDER: S-EPMC10470472 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature