Formate oxidation in the intestinal mucus layer enhances fitness of Salmonella enterica serovar Typhimurium.

ABSTRACT: Salmonella enterica serovar Typhimurium induces intestinal inflammation to create a niche that fosters the outgrowth of the pathogen over the gut microbiota. Under inflammatory conditions, Salmonella utilizes terminal electron acceptors generated as byproducts of intestinal inflammation to generate cellular energy through respiration. However, the electron donating reactions in these electron transport chains are poorly understood. Here, we investigated how formate utilization through the respiratory formate dehydrogenase-N (FdnGHI) and formate dehydrogenase-O (FdoGHI) contribute to gut colonization of Salmonella. Both enzymes fulfilled redundant roles in enhancing fitness in a mouse model of Salmonella-induced colitis, and coupled to tetrathionate, nitrate, and

SUBMITTER: Winter MG 

PROVIDER: S-EPMC10470504 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature