Novel macrolide-lincosamide-streptogramin B resistance gene erm(56) in Trueperella pyogenes.

ABSTRACT: Whole-genome sequence analysis of a macrolide, lincosamide, streptogramin B (MLS_B)-resistant Trueperella pyogenes from a dog revealed a new 23S ribosomal RNA methylase gene erm(56). Expression of the cloned erm(56) confers resistance to MLS_B in T. pyogenes and Escherichia coli. The erm(56) gene was flanked by two IS6100 integrated on the chromosome next to a sul1-containing class 1 integron. GenBank query revealed additional erm(56)-containing elements in another T. pyogenes and in Rothia nasimurium from livestock. IMPORTANCE A novel 23S ribosomal RNA methylase gene erm(56) flanked by insertion sequence IS6100 was identified in a Trueperella pyogenes isolated from the abs

SUBMITTER: Marchionatti E 

PROVIDER: S-EPMC10470526 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature