Anamnestic humoral correlates of immunity across SARS-CoV-2 variants of concern.

ABSTRACT: While immune correlates against SARS-CoV-2 are typically defined at peak immunogenicity following vaccination, immunologic responses that expand selectively during the anamnestic response following infection can provide mechanistic and detailed insights into the immune mechanisms of protection. Moreover, whether anamnestic correlates are conserved across variants of concern (VOC), including the Delta and more distant Omicron VOC, remains unclear. To define the anamnestic correlates of immunity, across VOCs, we deeply profiled the humoral immune response in individuals infected with sequence-confirmed Delta or Omicron VOC after completing the vaccination series. While limited acute N-terminal domain and receptor-binding domain (RBD)-specific immune expansion was observed following breakthro

SUBMITTER: McNamara RP 

PROVIDER: S-EPMC10470538 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature