Plasmodium microtubule-binding protein EB1 is critical for partitioning of nuclei in male gametogenesis.

ABSTRACT: Sexual reproduction of the malaria parasites is critical for their transmission to a mosquito vector. Several signaling molecules, such as kinases and phosphatases, are known to regulate this process. We previously demonstrated that Plasmodium falciparum (Pf) Ca²⁺-dependent protein kinase 4 (CDPK4) and serine/arginine-rich protein kinase 1 (SRPK1) are critical for axoneme formation during male gametogenesis, with genetic deletion of either gene causing a complete block in parasite transmission to the mosquito. A comparative phospho-proteome analysis of Pfcdpk4^- and RNA-seq analysis of Pfsrpk1^- gametocytes showed that these kinases regulate similar biological processes linked to both microtubule (MT) dynamics and cell motility. On

SUBMITTER: Mauer S 

PROVIDER: S-EPMC10470552 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature