Memory Th17 cell-mediated protection against lethal secondary pneumococcal pneumonia following influenza infection.

ABSTRACT: Streptococcus pneumoniae (Sp) frequently causes secondary pneumonia after influenza A virus (IAV) infection, leading to high morbidity and mortality worldwide. Concomitant pneumococcal and influenza vaccination improves protection against coinfection but does not always yield complete protection. Impaired innate and adaptive immune responses have been associated with attenuated bacterial clearance in influenza virus-infected hosts. In this study, we showed that preceding low-dose IAV infection caused persistent Sp infection and suppression of bacteria-specific T-helper type 17 (Th17) responses in mice. Prior Sp infection protected against subsequent IAV/Sp coinfection by improving bacterial clearance and rescuing bacteria-specific Th17 responses in the lu

SUBMITTER: Li Y 

PROVIDER: S-EPMC10470593 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature