Population structure and antimicrobial resistance patterns of <i>Salmonella</i> Typhi and Paratyphi A amid a phased municipal vaccination campaign in Navi Mumbai, India.

ABSTRACT: We performed whole-genome sequencing of 174 Salmonella Typhi and 54 Salmonella Paratyphi A isolates collected through prospective surveillance in the context of a phased typhoid conjugate vaccine introduction in Navi Mumbai, India. We investigate the temporal and geographical patterns of emergence and spread of antimicrobial resistance. We evaluated the relationship between the spatial distance between households and genetic clustering of isolates. Most isolates were non-susceptible to fluoroquinolones, with nearly 20% containing ≥3 quinolone resistance-determining region mutations. Two H58 isolates carried an IncX3 plasmid containing bla_SHV-12, associated with ceftriaxone resistance, suggesting that the ceftriaxone-resistant isolates from India independently evolv

SUBMITTER: da Silva KE 

PROVIDER: S-EPMC10470601 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature