Research into the mechanism of intervention of Wenjing decoction in endometriosis based on network pharmacology and molecular docking technology.

ABSTRACT:

Background

Endometriosis (EMs) is a frequent disease in women and is the principal cause of infertility and dysmenorrhea. Due to its high recurrence rate and serious complications, more research on EMs is needed. We used network pharmacology and molecular docking technology to predict the key active components, targets, and signaling pathways of Wen Jing decoction (WJD) in the treatment of EMs.

Methods

The components and targets of WJD were collected and identified using the Traditional Chinese Medicine Systems Pharmacology Database and BATMAN-TCM. The EMs targets were obtained from GeneCards, OMIM, TTD, Kyoto encyclopedia of genes and genomes (KEGG) and GAD Databases; the Venny diagram was used to analyze the overlap between the targets of WJD and EMs; use Cytoscape 3.8.2 s

SUBMITTER: Huang L 

PROVIDER: S-EPMC10470684 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature