Identification of the key mechanisms of action of Si-Ni-San in uveitis using bioinformatics and network pharmacology.

ABSTRACT:

Background

Uveitis is an eye disease with a high rate of blindness, whose pathogenesis is not completely understood. Si-Ni-San (SNS) has been used as a traditional medicine to treat uveitis in China. However, its mechanism of action remains unclear. This study explored the potential mechanisms of SNS in the treatment of uveitis through network pharmacology and bioinformatics.

Methods

Using R language and Perl software, the active components and predicted targets of SNS, as well as the related gene targets of uveitis, were mined through the Traditional Chinese Medicine Systems Pharmacology, Therapeutic Target, Gene Expression Omnibus, GeneCards, and DrugBank databases. The network diagram of active components and intersection targets was constructed using Cytoscape software a

SUBMITTER: Zhang D 

PROVIDER: S-EPMC10470687 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature