Targeting the metabolic profile of amino acids to identify the key metabolic characteristics in cerebral palsy.

ABSTRACT:

Background

Cerebral palsy (CP) is a neurodevelopmental disorder characterized by motor impairment. In this study, we aimed to describe the characteristics of amino acids (AA) in the plasma of children with CP and identify AA that could play a potential role in the auxiliary diagnosis and treatment of CP.

Methods

Using high performance liquid chromatography, we performed metabolomics analysis of AA in plasma from 62 CP children and 60 healthy controls. Univariate and multivariate analyses were then applied to characterize different AA. AA markers associated with CP were then identified by machine learning based on the Lasso regression model for the validation of intra-sample interactions. Next, we calculated a discriminant formula and generated a receiver operating characteri

SUBMITTER: Wang D 

PROVIDER: S-EPMC10470834 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature