Is serotonin transporter brain binding associated with the cortisol awakening response? An independent non-replication.

ABSTRACT:

Background

Serotonergic brain signaling is considered critical for an appropriate and dynamic adaptation to stress, seemingly through modulating limbic system functions, such as the hypothalamic-pituitary-adrenal (HPA)-axis. This interplay is of great interest since it holds promise as a target for preventing stress-related brain disorders, e.g., major depression. Our group has previously observed that prefrontal serotonin transporter (5-HTT) binding, imaged with positron emission tomography (PET), is positively associated with the cortisol awakening response (CAR), an index of HPA axis stress hormone dynamics. The aim of this cross-sectional study was to replicate the previous finding in a larger independent group of healthy individuals.

Methods

Molecular imaging and cortis

SUBMITTER: Conradi J 

PROVIDER: S-EPMC10470919 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature