Potential of GJA8 gene variants in predicting age-related cataract: A comparison of supervised machine learning methods.

ABSTRACT: Cataracts are the problems associated with the crystallins proteins of the eye lens. Any perturbation in the conformity of these proteins results in a cataract. Age-related cataract is the most common type among all cataracts as it accounts for almost 80% of cases of senile blindness worldwide. This research study was performed to predict the role of single nucleotide polymorphisms (SNPs) of the GJA8 gene with age-related cataracts in 718 subjects (400 age-related cataract patients and 318 healthy individuals). A comparison of supervised machine learning classification algorithm including logistic regression (LR), random forest (RF) and Artificial Neural Network (ANN) were presented to predict the age-related cataracts. The results indicated that LR is the best for predicting age-related c

SUBMITTER: Zafar S 

PROVIDER: S-EPMC10470928 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature