Metabolic modeling of sex-specific liver tissue suggests mechanism of differences in toxicological responses.

ABSTRACT: Male subjects in animal and human studies are disproportionately used for toxicological testing. This discrepancy is evidenced in clinical medicine where females are more likely than males to experience liver-related adverse events in response to xenobiotics. While previous work has shown gene expression differences between the sexes, there is a lack of systems-level approaches to understand the direct clinical impact of these differences. Here, we integrate gene expression data with metabolic network models to characterize the impact of transcriptional changes of metabolic genes in the context of sex differences and drug treatment. We used Tasks Inferred from Differential Expression (TIDEs), a reaction-centric approach to analyzing differences in gene expression, to discover that several

SUBMITTER: Moore CJ 

PROVIDER: S-EPMC10470949 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature