Understanding recurrent pregnancy loss: recent advances on its etiology, clinical diagnosis, and management.

ABSTRACT: Recurrent pregnancy loss (RPL) has become an important reproductive health issue worldwide. RPL affects about 2%-3% of reproductive-aged women, and makes serious threats to women's physical and mental health. However, the etiology of approximately 50% of RPL cases remains unknown (unexplained RPL), which poses a big challenge for clinical management of these patients. RPL has been widely regarded as a complex disease where its etiology has been attributed to numerous factors. Heretofore, various risk factors for RPL have been identified, such as maternal ages, genetic factors, anatomical structural abnormalities, endocrine dysfunction, prethrombotic state, immunological factors, and infection. More importantly, development and applications of next generation sequencing technology have sign

SUBMITTER: Cao C 

PROVIDER: S-EPMC10471095 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature