The latent reservoir of inducible, infectious HIV-1 does not decrease despite decades of antiretroviral therapy.

ABSTRACT: HIV-1 persists in a latent reservoir in resting CD4+ T cells despite antiretroviral therapy (ART). The reservoir decays slowly over the first 7 years of ART (t1/2 = 44 months). However, whether decay continues with long-term ART is unclear. Recent integration site studies indicate gradual selection against inducible, intact proviruses, raising speculation that decades of ART might allow treatment interruption without viral rebound. Therefore, we measured the reservoir in 42 people on long-term ART (mean 22 years) using a quantitative viral outgrowth assay. After 7 years of ART, there was no long-term decrease in the frequency of inducible, replication-competent proviruses but rather an increase with an estimated doubling time of 23 years. Another reservoir assay, the intact proviral DNA as

SUBMITTER: McMyn NF 

PROVIDER: S-EPMC10471168 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature