Left-right patterning in Xenopus conjoined twin embryos requires serotonin signaling and gap junctions.

ABSTRACT: A number of processes operating during the first cell cleavages enable the left-right (LR) axis to be consistently oriented during Xenopus laevis development. Prior work showed that secondary organizers induced in frog embryos after cleavage stages (i.e. conjoined twins arising from ectopic induced primary axes) correctly pattern their own LR axis only when a primary (early) organizer is also present. This instructive effect confirms the unique LR patterning functions that occur during early embryogenesis, but leaves open the question: which mechanisms that operate during early stages are also involved in the orientation of later-induced organizers? We sought to distinguish the two phases of LR patterning in secondary organizers (LR patterning of the primary twin and the later transfer of

SUBMITTER: Vandenberg LN 

PROVIDER: S-EPMC10471180 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature