Pedunculopontine Chx10⁺ neurons control global motor arrest in mice.

ABSTRACT: Arrest of ongoing movements is an integral part of executing motor programs. Behavioral arrest may happen upon termination of a variety of goal-directed movements or as a global motor arrest either in the context of fear or in response to salient environmental cues. The neuronal circuits that bridge with the executive motor circuits to implement a global motor arrest are poorly understood. We report the discovery that the activation of glutamatergic Chx10-derived neurons in the pedunculopontine nucleus (PPN) in mice arrests all ongoing movements while simultaneously causing apnea and bradycardia. This global motor arrest has a pause-and-play pattern with an instantaneous interruption of movement followed by a short-latency continuation from where it was paused. Mice naturally perform arres

SUBMITTER: Goni-Erro H 

PROVIDER: S-EPMC10471498 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature