Regional, circuit and network heterogeneity of brain abnormalities in psychiatric disorders.

ABSTRACT: The substantial individual heterogeneity that characterizes people with mental illness is often ignored by classical case-control research, which relies on group mean comparisons. Here we present a comprehensive, multiscale characterization of the heterogeneity of gray matter volume (GMV) differences in 1,294 cases diagnosed with one of six conditions (attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, depression, obsessive-compulsive disorder and schizophrenia) and 1,465 matched controls. Normative models indicated that person-specific deviations from population expectations for regional GMV were highly heterogeneous, affecting the same area in <7% of people with the same diagnosis. However, these deviations were embedded within common functional circuit

SUBMITTER: Segal A 

PROVIDER: S-EPMC10471501 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature